Nasogastric lansoprazole is effective in suppressing gastric acid secretion in critically ill patients
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1Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China. tsaiwl@vghtc.vghtc.gov.tw
Aim:
To evaluate the effect of nasogastric lansoprazole on acid suppression in critically ill patients.
Methods:
Patients were eligible for the study if they had a nasogastric tube in place and had not received acid-suppressive agents for 3 days prior to enrolment into the study. Patients with active gastrointestinal bleeding or a baseline gastric pH > 4.0 were excluded. Patients served as their own controls during a 24 h lead-in period. Lansoprazole 30 mg was administered once daily with water through a nasogastric tube for 2 days. Intragastric pH was measured by continuous 24 h pH-metry for 3 days.
Results:
Fifteen patients were enrolled into the study. The baseline median 24 h intragastric pH was 2.25 +/- 1.01, and increased to 6.70 +/- 0.82 (P= 0.001) after 2 days of lansoprazole. Mean percentage of time intragastric pH was > or = 4.0 was 25 +/- 13% at baseline, and increased to 84 +/- 14% (P=0. 001) after 2 days of lansoprazole.
Conclusions:
Nasogastric lansoprazole 30 mg daily is effective in suppressing gastric acid secretion in critically ill patients.
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