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Related Experiment Videos

Urticaria and hidden salicylates.

A L Wright1, A Minford

  • 1St. Luke's Hospital, Bradford, United Kingdom.

Pediatric Dermatology
|January 13, 2000
PubMed
Summary

Chronic urticaria in a toddler resolved after discontinuing pacifier use of topical salicylate. This case highlights a rare cause of persistent hives and the importance of a thorough patient history.

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Area of Science:

  • Pediatrics
  • Dermatology
  • Toxicology

Background:

  • Chronic urticaria can be challenging to manage in pediatric patients.
  • Antihistamine therapy is the first-line treatment for urticaria.
  • Identifying the underlying cause is crucial for effective treatment.

Observation:

  • A 23-month-old girl presented with chronic urticaria refractory to standard antihistamine treatments.
  • Investigation revealed the child was regularly applying a topical salicylate preparation to her pacifier.
  • This exposure was identified as a potential trigger for the persistent urticarial rash.

Findings:

  • Cessation of the topical salicylate application to the pacifier led to complete resolution of the chronic urticaria.
  • The patient remained urticaria-free after the intervention, indicating a direct causal link.
  • This suggests topical salicylate exposure can induce or exacerbate urticarial reactions.

Implications:

  • This case underscores the importance of a comprehensive patient history, including environmental and topical exposures, in diagnosing refractory pediatric urticaria.
  • Healthcare providers should consider non-allergic topical reactions as a potential cause of chronic hives.
  • Salicylate-containing topical preparations may warrant careful consideration for use in young children, especially in the context of pacifier use.

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