Increased sensitivity to oxidative challenges associated with topA deletion in Escherichia coli
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1Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA. yuk-ching_tse-dinh@nymc.edu
Journal of Bacteriology
|January 14, 2000
Abstract:
Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.

