Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acidosis and nutrition.

J D Louden1, R R Roberts, T H Goodship

  • 1Department of Nephrology, School of Clinical Medical Sciences, University of Newcastle upon Tyne, United Kingdom.

Kidney International. Supplement
|January 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombotic Microangiopathy as a Cause of Chronic Kidney Transplant Dysfunction: Case Report Demonstrating Successful Treatment with Eculizumab.

Transplantation proceedings·2015
Same author

A novel method for direct measurement of complement convertases activity in human serum.

Clinical and experimental immunology·2014
Same author

A guide to interpreting economic studies in infectious diseases.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2010
Same author

Infrared holograms recorded at 10.6 microm and reconstructed at 0.6328 microm.

Applied optics·2010
Same author

The role of neural activity in the migration and differentiation of enteric neuron precursors.

Neurogastroenterology and motility·2010
Same author

Solution structures of complement components by X-ray and neutron scattering and analytical ultracentrifugation.

Biochemical Society transactions·2002

Acidosis negatively impacts bodily systems, necessitating kidney acid secretion to maintain narrow extracellular fluid pH (7.35-7.45). Chronic kidney disease alters acidosis types as kidney function declines.

Area of Science:

  • Physiology
  • Nephrology
  • Biochemistry

Background:

  • Acidosis has detrimental effects on bodily systems, including nutrition.
  • Maintaining extracellular fluid (ECF) pH within a narrow range (7.35-7.45) is crucial for cellular function.
  • Acidosis is a process, while acidemia is the state of high ECF hydrogen ion concentration.

Purpose of the Study:

  • To differentiate between acidosis and acidemia.
  • To explain the buffering systems in the body.
  • To describe the progression of acidosis in chronic renal failure.

Main Methods:

  • Review of existing literature on acid-base balance and renal function.
  • Explanation of physiological buffering mechanisms (extracellular and intracellular).

Related Experiment Videos

  • Description of the changing types of acidosis in chronic kidney disease based on GFR.

    • Main Results:

    • The body produces approximately 70 mmol of hydrogen ions daily, requiring renal secretion for balance.
    • The carbonic acid/hydrogen carbonate system is the primary extracellular buffer.
    • In chronic renal failure, acidosis initially presents as non-anion gap, progressing to increased anion gap with declining GFR.

    Conclusions:

    • Acid-base balance is critical, with tight regulation of ECF pH.
    • Buffering systems are essential for managing endogenous acid production.
    • The type and severity of acidosis in chronic kidney disease correlate with the decline in glomerular filtration rate (GFR).