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Coagulation abnormalities in idiopathic portal venous thrombosis
1Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Journal of Gastroenterology and Hepatology
|January 14, 2000
Summary
Portal vein thrombosis is common in Indian patients. Lupus anticoagulant was found in two patients with portal vein thrombosis, suggesting a potential link.
Area of Science:
- Vascular Medicine
- Hematology
Background:
- Portal vein thrombosis (PVT) is a significant cause of portal hypertension in India, affecting 46% of patients presenting with variceal bleeding.
- Lupus anticoagulant (LA) and antithrombin III deficiency are known risk factors for venous thrombosis.
Purpose of the Study:
- To investigate the prevalence of lupus anticoagulant and antithrombin III deficiency in patients with portal vein thrombosis.
Main Methods:
- Ultrasound was used to diagnose portal venous thrombosis in 30 patients.
- Lupus anticoagulant and antithrombin III levels were assessed.
Main Results:
- Two out of 30 patients with PVT tested positive for lupus anticoagulant.
- These two patients also exhibited prolonged partial thromboplastin time with kaolin.
- No patients were found to have antithrombin III deficiency.
Conclusions:
- Lupus anticoagulant may be associated with portal vein thrombosis in some patients.
- Further research is needed to elucidate the role of lupus anticoagulant in PVT etiology.