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Related Experiment Videos

Probiotics and immune response.

S Cunningham-Rundles1, S Ahrné, S Bengmark

  • 1Cornell Medical Center, New York, New York 10021, USA.

The American Journal of Gastroenterology
|January 14, 2000
PubMed
Summary
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Oral probiotics like Lactobacillus plantarum 299v may help improve nutrient status and growth in children with human immunodeficiency virus (HIV). This study also explored its potential to modulate immune responses in this vulnerable population.

Area of Science:

  • Microbiology
  • Pediatric Infectious Diseases
  • Nutritional Science

Background:

  • Antibiotic-associated diarrhea and malabsorption are common in children with human immunodeficiency virus (HIV) infections.
  • These conditions can lead to growth abnormalities and compromised nutrient status.
  • Probiotics, specifically lactobacilli, show potential in managing gastrointestinal issues and restoring gut flora.

Purpose of the Study:

  • To investigate the efficacy of oral Lactobacillus plantarum 299v in improving nutrient status and promoting growth in children congenitally exposed to HIV.
  • To evaluate the immunomodulatory effects of Lactobacillus plantarum 299v supplementation in this pediatric population.
  • To assess the colonization potential of Lactobacillus plantarum 299v in the gastrointestinal tract of children with HIV.

Main Methods:

Related Experiment Videos

  • Oral administration of Lactobacillus plantarum 299v to children with HIV.
  • Monitoring of nutrient status and growth parameters.
  • Evaluation of systemic immune responses post-supplementation.
  • Assessment of probiotic colonization within the gastrointestinal tract.

Main Results:

  • Preliminary findings indicate that Lactobacillus plantarum 299v can colonize the gastrointestinal tract in children with HIV.
  • Oral supplementation with Lactobacillus plantarum 299v elicited a specific systemic immune response.
  • Further analysis is ongoing to determine effects on nutrient status and growth.

Conclusions:

  • Lactobacillus plantarum 299v demonstrates colonization capability and can stimulate an immune response in children with HIV.
  • These preliminary results suggest a potential therapeutic role for this probiotic in managing gastrointestinal and immune health in HIV-exposed children.
  • Further research is warranted to confirm benefits on growth and nutrient status.