Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Food-induced malabsorption syndromes.

¹Hospital for Children and Adolescents, University of Helsinki, Finland.

Journal of Pediatric Gastroenterology and Nutrition

|January 14, 2000

Summary

Infants with a cow's milk allergy experience chronic diarrhea and vomiting due to jejunal damage. This T-cell-mediated enteropathy resolves by age three, with intestinal healing after cow's milk elimination.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Perinatal probiotics decreased eczema up to 10 years of age, but at 5-10 years, allergic rhino-conjunctivitis was increased.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017

Same author

Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use.

Microbiome·2017

Same author

Up-regulation of small intestinal interleukin-17 immunity in untreated coeliac disease but not in potential coeliac disease or in type 1 diabetes.

Clinical and experimental immunology·2012

Same author

Intestinal defensin secretion in infancy is associated with the emergence of sensitization and atopic dermatitis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2011

Same author

Ovalbumin-specific immunoglobulins A and G levels at age 2 years are associated with the occurrence of atopic disorders.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2011

Same author

Serum immunoglobulin A concentration in infancy, but not human milk immunoglobulin A, is associated with subsequent atopic manifestations in children and adolescents: a 20-year prospective follow-up study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2011

Area of Science:

Pediatric Gastroenterology
Immunology
Allergy Research

Background:

A chronic infant syndrome of diarrhea, vomiting, and failure to thrive linked to cow's milk ingestion was identified.
Symptoms manifest early, presenting with malabsorption, anemia, and hypoproteinemia.

Purpose of the Study:

To investigate the immunologic and morphologic basis of cow's milk-induced enteropathy in infants.
To elucidate the role of T-cell mediated immune responses in jejunal damage.

Main Methods:

Histopathological examination of jejunal mucosa.
Immunohistochemical analysis of intraepithelial and lamina propria lymphocytes (CD4+, cytotoxic T-cells).
Assessment of immunoglobulin and cytokine profiles (IgA, IgG, IgE, interferon-gamma).

Main Results:

Jejunal damage characterized by villus atrophy, epithelial changes, and increased intraepithelial lymphocytes.
Elevated IgA and IgG antibodies to cow's milk, with positive cell-mediated immune indicators.
Increased cytotoxic T-cells (alpha/beta and gamma/delta T-cell receptors) and CD4+ T-cells in the lamina propria.
Elevated interferon-gamma secretion and eosinophil density.

Conclusions:

Cow's milk-induced enteropathy in infants is driven by a T-cell-mediated immune reaction in the small intestine.
The observed enteropathy and malabsorption are direct consequences of this immune response to cow's milk proteins.
Patients typically achieve tolerance to cow's milk by age three, with associated mucosal healing.

Related Experiment Videos