Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unloading does not increase brown-adipose-tissue activity in rat pups.

Y Ohira1, T Tanaka, M Segawa

  • 1Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya, Japan.

Research Communications in Molecular Pathology and Pharmacology
|January 14, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2).

Cytogenetics and cell genetics·2000
Same author

Effects of ageing on generation of ED2high major histocompatibility complex class II+ macrophages during cold stress.

Scandinavian journal of immunology·2000
Same author

[CD5 positive B cell leukemic lymphoma associated with BCL6 rearrangement].

[Rinsho ketsueki] The Japanese journal of clinical hematology·2000
Same author

Production of secretory component and pathogenesis of gastric cancer in Helicobacter pylori-infected stomach.

Journal of gastroenterology·2000
Same author

MT neurons in the macaque exhibited two types of bimodal direction tuning as predicted by a model for visual motion detection.

Vision research·2000
Same author

Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggering Fcgamma receptors.

Blood·1999
Same journal

Attenuation of bromobenzene-induced hepatotoxicity by poly(ADP-ribose) polymerase inhibitors.

Research communications in molecular pathology and pharmacology·2014
Same journal

Protective effect of tamoxifen, a synthetic non-steroidal antiestrogen, on phenelzine and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum.

Research communications in molecular pathology and pharmacology·2014
Same journal

Changes in monoamine oxidase activity in hepatic injury: a review.

Research communications in molecular pathology and pharmacology·2014
Same journal

Effects of 5-ethyl-1-phenyl-2-(1H) pyridone on serum biomarkers of multiorgan dysfunction and mortality in lipopolysaccharide/galactosamine and cecal ligation and puncture models of septic shock in mice.

Research communications in molecular pathology and pharmacology·2014
Same journal

The properties of B-form monoamine oxidase in mitochondria from monkey platelet.

Research communications in molecular pathology and pharmacology·2014
Same journal

Effect of antidepressant drug on semicarbazide-sensitive amine oxidase (SSAO) in dog brain.

Research communications in molecular pathology and pharmacology·2014
See all related articles

Chronic hindlimb suspension decreases brown adipose tissue (BAT) thermogenic activity in rat pups, unlike in adults. This suggests pups are less sensitive to unloading stress, impacting their energy metabolism.

Area of Science:

  • Physiology
  • Developmental Biology
  • Metabolism

Background:

  • Previous research indicated chronic hindlimb suspension increases brown adipose tissue (BAT) thermogenic capacity in adult rats.
  • The effects of unloading on BAT activity in developing animals remained unclear.

Purpose of the Study:

  • To investigate whether hindlimb unloading affects BAT thermogenic activity in rat pups.
  • To compare the response of BAT to unloading in pups versus adult rats.

Main Methods:

  • Rat pups underwent tail suspension from postnatal day 4 to 21.
  • Thermogenic activity was assessed by guanosine 5'-diphosphate binding to BAT mitochondria.
  • Uncoupling protein 1 (UCP1) content and mRNA expression were measured.

Related Experiment Videos

Main Results:

  • Suspended rat pups exhibited significantly lower BAT thermogenic activity compared to controls.
  • No differences were observed in UCP1 content or mRNA expression between groups.
  • Adrenal and thymus masses remained unchanged in suspended pups.

Conclusions:

  • Chronic hindlimb suspension decreases BAT thermogenic activity in rat pups.
  • This response contrasts with adult rats and may be due to pups' lower susceptibility to unloading stress.
  • Unloading impacts thermoregulation differently during development.