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Published on: February 23, 2017
Fabrication of microfluidic systems in poly(dimethylsiloxane)
J C McDonald1, D C Duffy, J R Anderson
1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Electrophoresis
|January 14, 2000
Summary
Poly(dimethylsiloxane) (PDMS) microfluidic devices offer a faster, cheaper alternative to traditional methods. Soft lithography enables accessible fabrication for various applications in chemistry and biology.
Area of Science:
- Materials Science
- Biotechnology
- Analytical Chemistry
Background:
- Microfluidic devices are increasingly used in analytical systems, biomedical applications, and fundamental research.
- Conventional fabrication methods using glass and silicon etching are often costly and require specialized facilities.
- There is a need for more accessible and cost-effective fabrication techniques for microfluidic devices.
Purpose of the Study:
- To describe the fabrication of microfluidic devices using poly(dimethylsiloxane) (PDMS) via soft lithography.
- To highlight the advantages of PDMS-based microfluidics over conventional methods.
- To showcase the application of these devices in separations and material patterning.
Main Methods:
- Soft lithography techniques, including rapid prototyping and replica molding, were employed.
- Poly(dimethylsiloxane) (PDMS) was used as the primary material for device fabrication.
- Fabrication was performed under benchtop conditions, avoiding the need for cleanroom facilities.
Main Results:
- PDMS microfluidic devices were successfully fabricated using soft lithography.
- These devices provide a faster and less expensive fabrication route compared to traditional glass and silicon methods.
- The fabricated devices are suitable for handling aqueous solutions and for applications such as separations and patterning.
Conclusions:
- Soft lithography of PDMS presents a practical and accessible method for microfluidic device fabrication.
- This approach democratizes microfluidic technology for chemists and biologists.
- PDMS microfluidics are versatile, enabling applications in integrated systems and material patterning.
