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Capillary electrophoresis on microchip.

V Dolník1, S Liu, S Jovanovich

  • 1Molecular Dynamics, Sunnyvale, CA 94086, USA. vdolnik@mdyn.com

Electrophoresis
|January 14, 2000
PubMed
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Microchip capillary electrophoresis has advanced significantly, enhancing separation techniques for nucleic acids and proteins. This review covers materials, designs, and applications of these powerful analytical tools.

Area of Science:

  • Analytical Chemistry
  • Biotechnology
  • Microfluidics

Background:

  • Capillary electrophoresis (CE) and related techniques have seen substantial advancements.
  • Microchip implementations offer miniaturized and integrated analytical systems.

Purpose of the Study:

  • To review recent progress in capillary electrophoresis on microchips.
  • To cover various CE techniques including capillary zone electrophoresis, isoelectric focusing, isotachophoresis, free flow electrophoresis, and micellar electrokinetic chromatography.
  • To highlight applications in nucleic acid and protein separation.

Main Methods:

  • Review of materials and technologies for microchip fabrication.
  • Analysis of microchip designs, channel geometries, and fluidic control.

Related Experiment Videos

  • Discussion of sample manipulation, derivatization, and detection strategies on-chip.
  • Examination of various capillary electrophoresis modes adapted for microchip platforms.

    • Main Results:

    • Significant progress in the development and application of microchip CE.
    • Demonstrated effectiveness of microchip CE for complex separations like nucleic acids and proteins.
    • Advancements in integrated sample preparation and detection systems on microchips.

    Conclusions:

    • Microchip capillary electrophoresis represents a major advancement in analytical separation science.
    • These integrated systems offer enhanced performance for biological molecule analysis.
    • Future developments are expected to further expand the capabilities of microchip-based CE.