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[Localized periarteritis nodosa with periostal new bone formation]
S Peron1, A Tilly-Gentric, P Hutin
1Service de médecine interne et maladies infectieuses, Hôpital de la Cavale Blanche, CHU, Brest, France.
La Revue De Medecine Interne
|January 15, 2000
Summary
Polyarteritis nodosa can present with skin changes and bone pain. This rare presentation includes periosteal bone formation, suggesting a need for considering this diagnosis.
Area of Science:
- Rheumatology
- Dermatology
- Pathology
Background:
- Polyarteritis nodosa (PAN) is a vasculitis with a broad clinical spectrum.
- Cutaneous PAN may be limited to skin, muscles, and nerves.
- Periosteal bone formation is an uncommon finding in PAN.
Observation:
- Two female patients (80 and 55 years) presented with painful leg nodules and bone pain.
- Histopathology revealed necrotizing arteritis in dermal and subcutaneous vessels.
- Radiographs demonstrated periosteal bone formation.
Findings:
- The cases illustrate an unusual manifestation of PAN with prominent periosteal reaction.
- Necrotizing arteritis of small and medium vessels was confirmed histologically.
- The combination of skin lesions, pain, and swelling in lower limbs warrants consideration of PAN with periostitis.
Implications:
- This presentation expands the known spectrum of cutaneous polyarteritis nodosa.
- Early consideration of PAN with periostitis may improve diagnostic timelines.
- Highlights the importance of integrating clinical, radiological, and pathological findings.