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Updated: Aug 15, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
[The immunotropic properties of the deoxyribonucleic acid from Salmonidae milt]
N N Besednova1, Iu I Kas'ianenko, L M Epshteĭn
1Research Institute of Epidemiology and Microbiology, Siberian Department, Russian Academy of Medical Sciences, Vladivostok.
Abstract:
The study of the immunotropic action of DNA from salmon milt showed that it increased the antiinfectious resistance of mice to Escherichia coli and Salmonella enteritidis, stimulated the antibody response to the thymus-dependent corpuscular antigen (sheep erythrocytes), increased the production of the antibody forming cells (AFC) in the murine spleen and intensified the absorptive and digestive activities of the cells of the mononuclear phagocytes. The immunotropic properties of the DNA permitted to broaden the DNA application spectrum with its supplementing by immunodeficiency of various genesis and diseases with phagocytic protection mechanisms. It is quite possible that the salmon milt DNA be used as a food additive.

