[Time-dependent effects of ramipril in patients with hypertension of 2 stage]

Time-related effects of ramipril were studied in 30 patients with essential hypertension stage II. Central hemodynamics, chronostructure of circadian rhythms of systolic, diastolic and mean arterial pressure, heart rate, double product were assessed before and after ramipril intake throughout 24 hours. The patients were randomized into 3 equal groups by time of ramipril administration: morning, afternoon and evening. Ramipril was given in dose 5 mg at 8 a.m., 14.00 or 17.00 and 20.00 p.m. Some hemodynamic parameters were measured each 4 hours. The data were analyzed using variation statistics and cosinor-analysis. Hypotensive effect of ramipril appeared approximately the same. Hemodynamics responded better after the evening intake of the drug.