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MRI study of human brain exposed to high-dose repetitive magnetic stimulation of visual cortex
L Niehaus1, K T Hoffmann, P Grosse
1Department of Neurology, Charité, Campus Virchow Klinikum, Humboldt-University, Berlin, Germany.
Neurology
|January 15, 2000
Abstract:
T1-, T2-, and diffusion-weighted MRI was used to determine whether repetitive transcranial magnetic stimulation (rTMS) affects the blood-brain barrier or induces localized brain edema. In 11 healthy individuals, 1,200 to 3,800 stimuli were applied over the visual cortex of one hemisphere in series of 5-, 10-, or 20-Hz stimulus trains. MRI performed 6 minutes to 6 hours after rTMS did not show pathologic changes in conventional MRI sequences, after application of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), or by determining apparent diffusion coefficients.