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Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues
Z Ye1, Y Gao, R K Bakshi
1Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
Abstract:
Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4.
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