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A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding
D Y Maeda1, W Williams, W D Bowen
1Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, USA.
Bioorganic & Medicinal Chemistry Letters
|January 15, 2000
Abstract:
A simple, achiral monoamine sigma-1 (sigma1) receptor selective ligand (sigma2Ki/sigma1Ki>2000) is described, which could replace the chiral (+)-pentazocine or dextrallorphan as a sigma1 masking agent in sigma2 binding assays.