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Related Experiment Videos

Relationship between thyroid hormones and fibrinogen levels.

R Chadarevian1, E Bruckert, P Giral

  • 1Hôpital Pitié Salpétrière, Paris, France. rita.chadarevian@psl.ap-hop-paris.fr

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|January 15, 2000
PubMed
Summary

Thyroid hormone levels impact blood clotting. Lower free thyroxine (FT4) is linked to higher fibrinogen, suggesting increased coagulation risk in individuals with normal-low FT4.

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Area of Science:

  • Endocrinology
  • Hematology
  • Clinical Biochemistry

Background:

  • Hypothyroidism can cause hemostatic abnormalities and bleeding.
  • Previous studies reported conflicting data on thyroid hormones and coagulation.
  • A large population study previously showed an inverse correlation between D-dimers and free thyroxine (FT4).

Purpose of the Study:

  • To investigate the relationship between fibrinogen levels and free thyroxine (FT4) in a large patient cohort.
  • To determine if this relationship is independent of age, sex, and smoking status.
  • To assess if FT4 levels correlate with a pro-coagulable state.

Main Methods:

  • Analysis of fibrinogen and FT4 levels in 959 patients.
  • Statistical correlation analysis (Pearson's r) was performed.

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  • Subgroup analyses were conducted for non-smokers and patients with strictly normal FT4 levels.

    • Main Results:

    • A significant inverse correlation was found between fibrinogen and FT4 levels (r = -0.12, P = 0.0001) in the overall population.
    • This inverse relationship persisted in non-smokers and patients with strictly normal FT4 levels.
    • Mean fibrinogen levels differed significantly between the lowest and highest FT4 subgroups, independent of age, sex, and smoking.

    Conclusions:

    • A negative and independent relationship exists between fibrinogen and FT4 levels.
    • Results suggest a tendency towards a more coagulable state in individuals with normal-low FT4 compared to normal-high FT4.
    • Findings support previous observations linking FT4 to hemostatic balance.