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Interstitial cystitis provoked by tiaprofenic acid
J Schou1, H L Jensen, C Frimodt-Møller
1Department of Urology, Gentofte University Hospital, Copenhagen, Denmark.
Scandinavian Journal of Urology and Nephrology
|January 15, 2000
Summary
Tiaprofenic acid, used for rheumatism, can cause interstitial cystitis. Discontinuing the drug led to complete symptom recovery and normalized bladder tissue, highlighting a reversible adverse effect.
Area of Science:
- Urology
- Pharmacology
- Rheumatology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for rheumatic conditions.
- Drug-induced adverse effects can manifest in various organ systems, including the urinary tract.
Observation:
- A patient undergoing treatment with tiaprofenic acid for rheumatism presented with symptoms and histological evidence of interstitial cystitis.
- Interstitial cystitis is a chronic condition characterized by bladder pain and urinary urgency.
Findings:
- Discontinuation of tiaprofenic acid resulted in complete resolution of the patient's interstitial cystitis symptoms.
- Follow-up bladder biopsies confirmed the normalization of detrusor muscle histology six months after drug cessation.
Implications:
- This case highlights the potential for tiaprofenic acid to induce interstitial cystitis as an adverse effect.
- The findings suggest that interstitial cystitis caused by tiaprofenic acid is reversible upon drug withdrawal.
- Clinicians should consider tiaprofenic acid-induced interstitial cystitis in patients presenting with relevant symptoms during treatment.
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