Resting heart rate and cardiac function in dilated cardiomyopathy

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I P Clements1, W L Miller, L J Olson

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. schwartz.roberta@mayo.edu

International Journal of Cardiology
|January 15, 2000
PubMed

Insights

Resting heart rate is inversely correlated with left ventricular ejection fraction and diastolic filling in patients with idiopathic dilated cardiomyopathy. This relationship was not observed in healthy individuals or those with ischemic dilated cardiomyopathy.

Area of Science:

  • Cardiology
  • Cardiac Physiology

Background:

  • Resting heart rate (RHR) is a key cardiovascular parameter.
  • Dilated cardiomyopathy (DCM) significantly impacts cardiac function.
  • Understanding the relationship between RHR and cardiac function in DCM is crucial for patient management.

Purpose of the Study:

  • To investigate the correlation between RHR and left ventricular (LV) function, specifically LV ejection fraction (LVEF) and diastolic filling, in patients with DCM.
  • To compare these correlations in patients with idiopathic DCM, ischemic DCM, and healthy controls.

Main Methods:

  • Radionuclide ventriculography was used to assess RHR, LVEF, and diastolic filling parameters (time to peak filling rate, peak filling rate, first half filling fraction).
  • Data were collected at rest from three groups: healthy subjects, patients with idiopathic DCM, and patients with ischemic DCM.

Main Results:

  • In idiopathic DCM, RHR showed significant inverse correlation with LVEF (r=-0.55, P=0.0007) and time to peak filling rate (r=-0.47, P=0.005), and a positive correlation with peak filling rate (r=0.73, P<0.0001).
  • Correlations were weak in healthy subjects and negligible in ischemic DCM.
  • Changes in RHR with LVEF and time to peak filling rate differed significantly between healthy controls and idiopathic DCM patients (P<0.05).

Conclusions:

  • RHR is significantly correlated with LVEF and diastolic filling parameters in patients with idiopathic DCM.
  • These correlations highlight the altered cardiac physiology in idiopathic DCM.
  • The findings suggest RHR can serve as a potential indicator of cardiac function in idiopathic DCM.

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