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Related Experiment Videos

Methotrexate and corticosteroid therapy for pediatric localized scleroderma.

Y Uziel1, B M Feldman, B R Krafchik

  • 1Division of Rheumatology and Pediatric Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

The Journal of Pediatrics
|January 15, 2000
PubMed
Summary

Methotrexate (MTX) combined with corticosteroids shows promise for treating localized scleroderma (LS). This therapy led to inactive skin lesions in most patients, suggesting it is effective and well-tolerated for LS management.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pediatric Rheumatology

Background:

  • Localized scleroderma (LS) is a disabling condition with limited treatment options.
  • Methotrexate (MTX) has demonstrated efficacy in treating systemic sclerosis.
  • Effective therapeutic strategies for LS remain an unmet clinical need.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of Methotrexate (MTX) and corticosteroid therapy in pediatric patients diagnosed with localized scleroderma (LS).

Main Methods:

  • Ten pediatric patients with active LS received MTX (0.3-0.6 mg/kg/week).
  • Nine patients concurrently received pulse intravenous methylprednisolone (30 mg/kg/day for 3 days monthly for 3 months).

Main Results:

Related Experiment Videos

  • Nine out of ten patients responded to MTX therapy, with a median response time of 3 months.
  • All patients continuing MTX showed inactive skin lesions at the final follow-up.
  • The combined therapy was generally well-tolerated, with manageable side effects.

Conclusions:

  • Combined MTX and corticosteroid treatment appears effective and well-tolerated for localized scleroderma.
  • Further investigation via placebo-controlled trials is warranted to confirm MTX efficacy in LS.