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Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40
N Garceau1, Y Kosaka, S Masters
1Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
The Journal of Experimental Medicine
|January 19, 2000
Abstract:
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40.