Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Targeting multi-stranded DNA structures.

T C Jenkins1

  • 1Yorkshire Cancer Research Laboratory of Drug Design, University Cancer Medicine Unit, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK. t.c.jenkins@brad.ac.uk

Current Medicinal Chemistry
|January 19, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of bismuth subsalicylate and dietary sulfur level on fermentation by ruminal microbes in continuous culture.

Translational animal science·2020
Same author

Corrigendum to "Changes in fermentation and animal performance during recovery from classical diet-induced milk fat depression using corn with differing rates of starch degradability" (J. Dairy Sci. 102:5079-5093).

Journal of dairy science·2019
Same author

Changes in fermentation and animal performance during recovery from classical diet-induced milk fat depression using corn with differing rates of starch degradability.

Journal of dairy science·2019
Same author

Short communication: Field study to investigate the associations between herd-level risk factors for milk fat depression and bulk tank milk fat percent in dairy herds feeding monensin.

Journal of dairy science·2018
Same author

A 100-Year Review: Fat feeding of dairy cows.

Journal of dairy science·2017
Same author

Short communication: Temporal effect of feeding potassium carbonate sesquihydrate on milk fat in lactating dairy cows fed a fat-depressing diet.

Journal of dairy science·2016
Same journal

Unlocking the Prognostic Power of the m-CALLY Index in Cardiovascular-Kidney-Metabolic Syndrome.

Current medicinal chemistry·2026
Same journal

Ferritinophagy-Related Genes in Breast Cancer: Insights from Multi-Omics Analysis.

Current medicinal chemistry·2026
Same journal

Research Progress on Natural Products and Synergistic Nanostrategies for Targeting Ferroptosis in Osteosarcoma.

Current medicinal chemistry·2026
Same journal

Revealing Antihypertensive Drugs for Reducing NAFLD Risk: Genetic Evidence from a Mendelian Randomization Study.

Current medicinal chemistry·2026
Same journal

Identification of Diagnostic Biomarkers Related to Oxidative Stress in Rheumatoid Arthritis.

Current medicinal chemistry·2026
Same journal

Mechanistic Insights into Ginkgo Biloba Extract's Anti-Inflammatory Effects in COPD: Regulation of Th1/Th2 Balance via the p38 MAPK Pathway.

Current medicinal chemistry·2026
See all related articles

This study designs agents for recognizing DNA triplexes and tetraplexes, crucial for antigene therapies and telomerase inhibition. Chemical modifications enhance DNA drug binding affinity and specificity for targeted treatments.

Area of Science:

  • Medicinal Chemistry
  • Molecular Biology
  • Drug Design

Background:

  • DNA triplexes and tetraplexes are key targets for antigene-based chemotherapies and telomerase inhibition.
  • Developing specific ligands for these higher-order DNA structures presents unique challenges in drug design.

Purpose of the Study:

  • To develop a rational approach for designing structure-specific molecular recognition agents targeting DNA triplexes and tetraplexes.
  • To enhance the affinity and specificity of DNA-drug binding interactions for therapeutic applications.

Main Methods:

  • Utilizing principles from synthetic duplex-binding ligands and recent thermodynamic/kinetic stability data.
  • Employing structure-specific or structure-preferential recognition strategies.
  • Chemical manipulation including geometric isomers, charge/H-bond redistribution, and pi-overlap optimization.

Related Experiment Videos

Main Results:

  • Demonstrated structure-specific recognition and stabilization of DNA triplexes via intercalative or groove-mediated binding.
  • Successfully targeted DNA tetraplexes using planar extended-aromatic ligands.
  • Showcased chemical modifications to improve DNA drug binding affinity and specificity.

Conclusions:

  • A rational design strategy can exploit unique DNA triplex and tetraplex structures for targeted therapies.
  • Analytical techniques can augment conventional drug design, especially with limited structural information.
  • Chemical manipulation offers a powerful means to optimize DNA-drug interactions for improved therapeutic efficacy.