Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Structure and function in the p53 family.

C H Arrowsmith¹

¹Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Ave., Toronto, Ontario, Canada M5G 2M9. carrow@oci.utoronto.ca

Cell Death and Differentiation

|January 19, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chemical Biology Approaches for Characterization of Epigenetic Regulators.

Methods in enzymology·2016

Same author

Optimization of resolution and sensitivity of 4D NOESY using multi-dimensional decomposition.

Journal of biomolecular NMR·2005

Same author

NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum.

Journal of structural and functional genomics·2003

Same author

Structural genomics: current progress.

Science (New York, N.Y.)·2003

Same author

X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold.

Proteins·2001

Same author

Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.

Structure (London, England : 1993)·2001

Same journal

Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis.

Cell death and differentiation·2026

Same journal

Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.

Cell death and differentiation·2026

Same journal

Ssu72 phosphatase orchestrates obesogenic adipogenesis and metabolic homeostasis during nutrient excess.

Cell death and differentiation·2026

Same journal

SETD7 depletion enhances white adipose browning and ameliorates metabolic disorders in obese mice.

Cell death and differentiation·2026

Same journal

LFPM inhibition of RING1-mediated p53<sup>R175H</sup> degradation drives oncogenesis in p53<sup>R175H</sup>-mutant cancers.

Cell death and differentiation·2026

Same journal

Cell engulfment defines spatially distinct competitive metabolic niches associated with clinical outcomes in colorectal cancer.

Cell death and differentiation·2026

See all related articles

The p53 superfamily, including p63 and p73, regulates cell cycle arrest and apoptosis. A novel SAM domain in p63/p73 may mediate protein interactions during development.

Area of Science:

Molecular Biology
Genetics
Cell Biology

Background:

The p53 superfamily of transcription factors plays crucial roles in cell cycle regulation and apoptosis.
Recent discoveries have expanded the known p53 family, necessitating a deeper understanding of these related proteins.

Purpose of the Study:

To review the current understanding of the structure-function relationships within the p53 superfamily.
To highlight similarities and differences in regulation and interaction potential among p53 family members.

Main Methods:

Review of recent scientific literature on p53 family members.
Analysis of conserved domains, including the C-terminal SAM domain.
Examination of protein-protein interaction data and splice variant interactions.

Related Experiment Videos

Main Results:

p63 and p73 possess a conserved C-terminal SAM domain, potentially involved in protein-protein interactions and regulatory functions.
While oligomerization domains are conserved across the p53 family, they primarily mediate interactions between splice variants of the same gene, not between different family members.

Conclusions:

The C-terminal SAM domain in p63 and p73 represents a key area for understanding their unique regulatory roles and involvement in developmental processes.
Understanding the specific interaction patterns of p53 family members and their splice variants is crucial for deciphering their distinct biological functions.