Intracellular copper routing: the role of copper chaperones
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Updated: Sep 20, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
M D Harrison1, C E Jones, M Solioz
1Department of Biochemistry and Genetics, The Medical School, University of Newcastle, UK NE2 4HH.
Abstract:
Copper is required by all living systems. Cells have a variety of mechanisms to deal with this essential, yet toxic trace element. A recently discovered facet of homeostatic mechanisms is the protein-mediated, intracellular delivery of copper to target proteins. This routing is accomplished by a novel class of proteins, the 'copper chaperones'. They are a family of conserved proteins present in prokaryotes and eukaryotes, which suggests that copper chaperones are used throughout nature for intracellular copper routing.
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