Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular dementia today.

G C Román1

  • 1Dept Medicine/Neurology, UT Health Science Center, San Antonio 78284-7883, USA. romang@uthscsa.edu

Revue Neurologique
|January 19, 2000
PubMed
Summary
This summary is machine-generated.

Vascular dementia (VaD) is a significant cause of senile dementia, with various pathological mechanisms contributing to its development. Controlling vascular risk factors like hypertension offers hope for preventing VaD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The COVID-19 pandemic, an environmental neurology perspective.

Revue neurologique·2022
Same author

Environmental neurology in the tropics.

Journal of the neurological sciences·2021
Same author

Medical management, prevention and mitigation of environmental risks factors in Neurology.

Revue neurologique·2019
Same author

The World Federation of Neurology and the challenges in Environment Neurology.

Revue neurologique·2019
Same author

Extra-virgin olive oil for potential prevention of Alzheimer disease.

Revue neurologique·2019
Same author

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.

Revue neurologique·2019
Same journal

Macrophage inclusions in patients undergoing antisense oligonucleotide therapy for ALS or SMA: A retrospective and transversal study.

Revue neurologique·2026
Same journal

Geographic disparities in MRI features of ischemic stroke and small vessel disease: A comparative study between French Guiana and mainland France. Findings from the BECATOUR multicenter registry.

Revue neurologique·2026
Same journal

Continuous subcutaneous perfusion of apomorphine in Parkinson's disease: Towards monotherapy?

Revue neurologique·2026
Same journal

Neuro-Whipple presenting as autoimmune encephalitis.

Revue neurologique·2026
Same journal

Multimodal assessment of minimally conscious state and cognitive motor dissociation in neurocritical care: A critical review.

Revue neurologique·2026
Same journal

Development of a new episodic memory assessment tool (NEM): Preliminary data and clinical perspectives.

Revue neurologique·2026
See all related articles

Area of Science:

  • Neurology
  • Geriatrics
  • Pathology

Background:

  • Vascular dementia (VaD) is a growing cause of senile dementia, with evolving diagnostic criteria.
  • Pathogenetic mechanisms beyond multi-infarct dementia are crucial in VaD.
  • Ischemic lesions, including lacunes and white matter changes, impact frontal executive functions and can co-occur with Alzheimer's disease.

Purpose of the Study:

  • To review the current understanding of vascular dementia (VaD) and its pathogenesis.
  • To discuss the clinical presentations and underlying mechanisms of VaD.
  • To highlight potential prevention strategies for VaD.

Main Methods:

  • Literature review of recent diagnostic criteria and research on VaD.
  • Analysis of pathogenetic mechanisms including strokes, hypoxic-ischemic events, and white matter lesions.

Related Experiment Videos

  • Discussion of clinical subtypes and genetic factors (e.g., CADASIL).

    • Main Results:

    • VaD involves diverse mechanisms like subcortical strokes and Binswanger-type lesions, affecting executive functions.
    • Acute VaD includes large-vessel infarction and lacunar dementia; subacute VaD includes Binswanger's disease and CADASIL.
    • The genetic basis of CADASIL provides insights into Binswanger's disease pathogenesis.

    Conclusions:

    • VaD encompasses various ischemic vascular lesions contributing to cognitive decline.
    • Understanding these mechanisms, including genetic factors, is key to advancing VaD research.
    • Epidemiological data suggest that managing vascular risk factors, such as hypertension, may prevent VaD and other dementias.