Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Therapy refractory depression].

M Hatzinger1, E Holsboer-Trachsler

  • 1Psychiatrischen Universitätsklinik Basel, Schweiz. martin.hatzinger@pokbasel.ch

Wiener Medizinische Wochenschrift (1946)
|January 19, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The long journey from palpation to biopsy : The history of diagnosing prostate cancer].

Der Urologe. Ausg. A·2020
Same author

Assessing physical activity in people with mental illness: 23-country reliability and validity of the simple physical activity questionnaire (SIMPAQ).

BMC psychiatry·2020
Same author

[The history of kidney transplantation].

Der Urologe. Ausg. A·2016
Same author

[Hypospadia and infertility of Henry II of France (1519-1559)].

Der Urologe. Ausg. A·2014
Same author

[Genital reassignment surgery in male-to-female transsexuals: do we have guidelines or standards?].

Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...·2013
Same author

[Dimitrij Oscarovic Ott (1855-1929) "Ventroscopy" : His contribution to development of laparoscopy].

Der Urologe. Ausg. A·2013
Same journal

Necrotizing fasciitis of the thigh-a devastating sign of intestinal perforation.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Regenerative therapies in rehabilitation with interfaces with occupational medicine, geriatrics, and oncology: the example of extracorporeal shock wave therapy.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Cerebral toxoplasmosis in patients with peripheral B-cell lymphoma : A case series and a literature review.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Post-pandemic rebound of rotavirus and adenovirus in pediatric gastroenteritis: a 6-year antigen-based surveillance study from Turkey.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Neuroaxis involvement in Chikungunya virus infection: a retrospective case series.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

A complicated case of a spinal Scedosporium apiospermum infection with a favorable outcome-case report.

Wiener medizinische Wochenschrift (1946)·2026
See all related articles

Treatment-resistant depression requires reassessment of antidepressant dosage and duration. Strategies like switching drugs, combining antidepressants, augmentation with lithium or thyroid hormone, or partial sleep deprivation can improve patient outcomes.

Area of Science:

  • Psychiatry
  • Pharmacology

Context:

  • Defines treatment-resistant depression based on standard antidepressant trial failure.
  • Highlights the significant number of patients inadequately treated under current guidelines.
  • Emphasizes the need for reassessment of antidepressant dosage and treatment duration.

Purpose:

  • To outline strategies for managing treatment-resistant depression.
  • To discuss alternative pharmacological and non-pharmacological interventions.
  • To review augmentation and adjunctive therapies for refractory depression.

Summary:

  • Treatment-resistant depression occurs when standard antidepressant trials fail.
  • Effective strategies include switching to alternative drugs, combining biochemically different antidepressants, or using augmentation therapies.

Related Experiment Videos

  • Well-studied augmentation options include lithium and thyroid hormone (T3).
  • Partial sleep deprivation and electroconvulsive therapy (ECT) are also effective options for non-responders.

    • Impact:

    • Provides a framework for clinicians to manage patients with treatment-resistant depression.
    • Suggests evidence-based alternative treatments to improve patient outcomes.
    • Highlights the importance of personalized treatment approaches in psychiatry.