Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Increasing Function01:18

Increasing Function

389
An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...
389
Half-life of a Reaction02:42

Half-life of a Reaction

38.9K
The half-life of a reaction (t1/2) is the time required for one-half of a given amount of reactant to be consumed. In each succeeding half-life, half of the remaining concentration of the reactant is consumed. For example, during the decomposition of hydrogen peroxide, during the first half-life (from 0.00 hours to 6.00 hours), the concentration of H2O2 decreases from 1.000 M to 0.500 M. During the second half-life (from 6.00 hours to 12.00 hours), the concentration decreases from 0.500 M to...
38.9K
Transgenic Organisms00:53

Transgenic Organisms

33.4K
Overview
33.4K
Characteristics of Life01:23

Characteristics of Life

260.4K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
260.4K
The Angiosperm Life Cycle02:39

The Angiosperm Life Cycle

72.4K
Plants have a life cycle split between two multicellular stages: a haploid stage—with cells containing one set of chromosomes—and a diploid stage—with cells containing two sets of chromosomes. The haploid stage is the gamete-producing gametophyte, and the diploid stage is the spore-producing sporophyte.
72.4K
Spanning Openings in Brick Walls01:20

Spanning Openings in Brick Walls

570
In brick wall construction, supporting structures are crucial for openings like windows and doors to maintain the integrity and support the weight of the wall above. These supports include lintels, corbels, and arches, each serving specific structural purposes.
Lintels are primary supports used to span openings and can be crafted from materials such as reinforced concrete, steel-reinforced brick masonry, or simple steel angles. These are straightforward to install and are typically concealed...
570

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of genetic selection for fast growth on the development of wooden breast myopathy in broilers.

British poultry science·2023
Same author

Post-Hatch Performance of Broilers Following Hypoxic Exposure During Incubation Under Suboptimal Environmental Temperature.

Frontiers in physiology·2022
Same author

Effects of hypoxic conditions during the plateau period on pre- and posthatch broiler performance.

Poultry science·2021
Same author

Effects of low oxygen during chorioallantoic membrane development on post-hatch growing performance of broiler chickens.

Poultry science·2018
Same author

Thermal treatments prior to and during the beginning of incubation affects development of the broiler embryo and yolk sac membranes, and live performance and carcass characteristics.

Poultry science·2017
Same author

Adaptive energy metabolism in four chromosomal species of subterranean mole rats.

Oecologia·2017

Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
04:20

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

2.5K

AlphaMUPA mice: a transgenic model for increased life span.

R Miskin1, T Masos, S Yahav

  • 1Department of Biological Chemistry and Immunology, The Weizmann Institute of Science, Rehovot, Israel. Ruth.Miskin@weizmann.ac.il

Neurobiology of Aging
|January 19, 2000
PubMed
Summary

Transgenic mice (alphaMUPA) exhibit reduced eating and extended lifespan, mimicking dietary restriction. These mice show altered body temperature and corticosterone levels, offering a unique model for studying aging.

More Related Videos

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
06:49

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Published on: February 12, 2018

11.5K
Measuring Caenorhabditis elegans Life Span on Solid Media
12:49

Measuring Caenorhabditis elegans Life Span on Solid Media

Published on: May 11, 2009

30.9K

Related Experiment Videos

Last Updated: Jan 29, 2026

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
04:20

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

Published on: July 12, 2024

2.5K
Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
06:49

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Published on: February 12, 2018

11.5K
Measuring Caenorhabditis elegans Life Span on Solid Media
12:49

Measuring Caenorhabditis elegans Life Span on Solid Media

Published on: May 11, 2009

30.9K

Area of Science:

  • Aging research
  • Genetics
  • Physiology

Background:

  • Dietary restriction (DR) is known to extend lifespan and delay aging.
  • Transgenic models offer insights into aging mechanisms.
  • AlphaMUPA mice spontaneously exhibit DR-like phenotypes.

Purpose of the Study:

  • To characterize the physiological and phenotypic differences between alphaMUPA mice and wild-type (WT) counterparts.
  • To investigate the role of urokinase (uPA) in the observed phenotypes.
  • To evaluate alphaMUPA mice as a model for studying aging.

Main Methods:

  • Comparison of alphaMUPA and WT mice across various ages.
  • Measurement of body temperature and plasma corticosterone levels.
  • Analysis of thymus involution and uPA expression in the brain.

Main Results:

  • AlphaMUPA mice showed reduced body temperature and altered corticosterone profiles compared to WT.
  • Age-associated thymus involution occurred in both alphaMUPA and WT mice.
  • Widespread uPA mRNA expression, particularly in the hypothalamus, was unique to alphaMUPA mice.

Conclusions:

  • AlphaMUPA mice partially resemble DR animals but exhibit unique characteristics, including uPA expression.
  • Transgenic uPA in the brain is hypothesized to cause the observed phenotypic alterations.
  • AlphaMUPA mice provide a novel model for investigating delayed aging and its homeostatic regulation.