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Non-quantal acetylcholine release is increased after nitric oxide synthase inhibition
M R Mukhtarov1, F Vyskocil, A K Urazaev
1Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Russia.
Physiological Research
|January 19, 2000
Abstract:
After anticholinesterase treatment, depolarization of the postsynaptic muscle membrane by about 5 mV develops due to non-quantally released acetylcholine from the motor nerve terminal and can be revealed as hyperpolarization by the addition of curare (H-effect). The H-effect increases significantly to 8.7 mV after inhibition of NO-synthase by L-nitroarginine methylester (L-NAME) whilst no changes in the amplitude and frequency of quantal miniature endplate potentials are observed.