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Candida albicans-derived beta-1,2-linked mannooligosaccharides induce desensitization of macrophages
T Jouault1, C Fradin, P A Trinel
1Laboratoire de Mycologie Fondamentale et Appliquée, INSERM E9915, Université de Lille II, Faculté de Médecine H. Warembourg, Lille, France. tjou@worldnet.fr
Infection and Immunity
|January 20, 2000
Abstract:
Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha) but not NO release. This stimulation desensitized macrophages by altering beta-1, 2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.