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Related Experiment Videos

Immediate response to expiratory threshold load.

E D'angelo, E Agostoni

    Respiration Physiology
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    The first breath volume increased during expiratory threshold load (ETL) in animals, driven by lung mechanics, not chest wall signals. Vagotomy abolished this inspiratory response, highlighting the role of vagal nerve feedback.

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    Area of Science:

    • Respiratory Physiology
    • Pulmonary Mechanics
    • Neuroscience

    Background:

    • The mechanics of the first breath following an expiratory load are crucial for understanding respiratory control.
    • Expiratory threshold loading (ETL) presents a unique challenge to the respiratory system, potentially altering inspiratory responses.

    Purpose of the Study:

    • To investigate the determinants of the increased end-inspiratory volume during the first breath under expiratory threshold load (ETL).
    • To elucidate the role of afferent signals from the chest wall and vagal nerve pathways in this respiratory response.

    Main Methods:

    • Experiments were conducted on anesthetized rabbits, cats, and dogs.
    • Measurements included end-inspiratory volume (deltaVe.i.) and end-expiratory volume (deltaVe.e.) relative to functional residual capacity (FRC).

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  • Interventions included ETL, chest wall compression, abdominal compression, cordotomy, and bilateral vagotomy.

    • Main Results:

    • The end-inspiratory volume of the first breath during ETL was significantly greater than control.
    • This increase was proportional to the rise in end-expiratory volume caused by ETL.
    • The phenomenon persisted despite chest wall manipulation or cordotomy, but was abolished by bilateral vagotomy.
    • Inspiratory delay during ETL correlated with increased end-expiratory volume, without significant changes in arterial PCO2.

    Conclusions:

    • Afferent impulses from the chest wall are not essential for the increased inspiratory volume during ETL.
    • The observed phenomenon is primarily dependent on vagal nerve feedback.
    • The findings support an explanation based on the respiratory center's tidal volume-inspiratory duration characteristics, modulated by vagal input.