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Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein
1Geriatric Research Education and Clinical Center, Sepulveda VAMC and Department of Medicine, UCLA, 16111 Plummer Street, Sepulveda, CA, USA.
Brain Research
|January 21, 2000
Abstract:
Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of alpha-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human betaAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and alpha-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD.