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Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid
Background:
9-cis-Retinoic acid (9-cis-RA) has a particular pattern of binding and activating retinoid receptors. Treatment of chronic hand eczema is often refractory to conventional treatment.
Objective:
Evaluation of oral 9-cis-RA therapy in chronic hand eczema in a pilot study.
Methods:
Thirty-eight patients with refractory chronic hand eczema were treated in an exploratory open-label study with oral 9-cis-RA.
Results:
Twenty-one (55%) showed a very good response, 13 (34%) a good response, 2 (5.5%) a moderate response and 2 (5.5%) no response. Side effects were mild.
Conclusion:
9-cis-RA is a valuable drug when given at low doses to patients with chronic hand eczema.
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