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Management of cutaneous verruciform xanthoma
S B Connolly1, E J Lewis, J S Lindholm
1Department of Dermatology, University of Minnesota, Minneapolis, USA.
Journal of the American Academy of Dermatology
|January 21, 2000
Summary
Verruciform xanthoma, a rare skin condition, involves foamy histiocytes. Degenerating keratinocytes likely provide the lipid source, with wide surgical excision showing preliminary success for cutaneous lesions.
Area of Science:
- Dermatology
- Pathology
Background:
- Verruciform xanthoma is a rare mucocutaneous condition with unknown etiology.
- Histopathology reveals foamy histiocytes in elongated dermal papillae.
- Cutaneous lesion treatment remains largely unreported, unlike intraoral cases.
Observation:
- A 62-year-old male presented with extensive verruciform xanthoma in bilateral inguinal folds.
- Immunohistochemistry, RT-PCR for human papilloma virus, and ultrastructural analysis were conducted.
- Initial treatments including electrosection, pulsed dye laser, and x-ray therapy were ineffective.
Findings:
- The study supports degenerating keratinocytes as the source of lipid in dermal histiocytes.
- This finding offers insight into the pathogenesis of verruciform xanthoma.
- Wide surgical excision with primary closure demonstrated preliminary therapeutic success.
Implications:
- This research contributes to understanding verruciform xanthoma pathogenesis.
- It highlights the challenges and potential efficacy of surgical management for cutaneous lesions.
- Further investigation into optimal treatment strategies for skin verruciform xanthoma is warranted.
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