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CNS activity of Vitex negundo Linn. in mice
M Gupta1, U K Mazumder, S R Bhawal
1Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Indian Journal of Experimental Biology
|January 21, 2000
Abstract:
Methanolic extract (ME) of the leaves of V. negundo potentiated significantly the sleeping time induced by pentobarbitone sodium, diazepam and chlorpromazine in mice. ME possesses analgesic properties and potentiated analgesia induced by morphine and pethidine. ME also showed significant protection against strychnine and leptazole induced convulsions. The results suggest that ME exhibits CNS depressant activity in a dose dependent manner.