Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating immune complex in murine autoimmune hepatitis.

D Chattopodhyay1, M R Sen

  • 1Department of Microbiology, Banaras Hindu University, Varanasi, India.

Indian Journal of Experimental Biology
|January 21, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rupture of liver in horses during hyperimmunization.

The Indian veterinary journal·2014
Same author

Sarcosporidiosis in cattle in Bengal.

The Indian veterinary journal·2014
Same author

Co-existence of Pseudomonas-derived cephalosporinase among plasmid encoded CMY-2 harbouring isolates of Pseudomonas aeruginosa in north India.

Indian journal of medical microbiology·2013
Same author

Prevalence of Serum Antibodies to TORCH Infection in and Around Varanasi, Northern India.

Journal of clinical and diagnostic research : JCDR·2013
Same author

Burden of different beta-lactamase classes among clinical isolates of AmpC-producing Pseudomonas aeruginosa in burn patients: A prospective study.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2012
Same author

Observation on integron carriage among clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases.

Indian journal of medical microbiology·2010

Elevated circulating immune complexes (CIC) are linked to experimental autoimmune hepatitis (EAH) in mice. This study found significantly higher CIC levels, measured by the polyethylene glycol (PEG) index, in EAH models compared to healthy controls.

Area of Science:

  • Immunology
  • Hepatology
  • Biochemistry

Background:

  • Circulating immune complexes (CIC) are implicated in various hepatitis forms, especially complicated viral hepatitis B (HBV).
  • Understanding CIC's role in autoimmune liver disease is crucial for developing targeted therapies.

Purpose of the Study:

  • To assess CIC levels in experimental autoimmune hepatitis (EAH) using the polyethylene glycol (PEG) index.
  • To investigate the correlation between elevated CIC and the pathogenesis of EAH.

Main Methods:

  • Experimental autoimmune hepatitis (EAH) was induced in C57BL/6 and C3H mice.
  • Serum CIC levels were quantified using the polyethylene glycol (PEG) precipitation assay.
  • Histopathological examination confirmed EAH in affected mice.

Related Experiment Videos

Main Results:

  • Mice with EAH exhibited significantly higher PEG index values (C57BL/6: 34.56 ± 6.28; C3H: 31.95 ± 28.99) compared to healthy controls (C57BL/6: 19.48 ± 6.85; C3H: 21.27 ± 6.1).
  • The elevated PEG index in EAH mice was statistically significant, indicating higher CIC levels.

Conclusions:

  • The study demonstrates a significant elevation of CIC in experimental autoimmune hepatitis.
  • These findings support a potential role for CIC in the development and progression of autoimmune hepatitis.