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Related Experiment Videos

Serum-gastrin in cirrhosis.

K B Lauritsen, J F Rehfeld, L A Christiansen

    Scandinavian Journal of Gastroenterology. Supplement
    |January 1, 1976
    PubMed
    Summary

    Patients with cirrhosis of the liver often have high serum gastrin levels. This hypergastrinemia was more common in non-alcoholic cirrhosis and inactive liver disease.

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    Area of Science:

    • Gastroenterology
    • Hepatology
    • Endocrinology

    Background:

    • Cirrhosis of the liver is a significant global health concern.
    • Elevated gastrin levels (hypergastrinemia) have been observed in various gastrointestinal conditions.
    • Understanding gastrin's role in liver disease is crucial for patient management.

    Purpose of the Study:

    • To investigate serum gastrin concentrations in patients with cirrhosis.
    • To compare gastrin levels between alcoholic and non-alcoholic cirrhosis.
    • To assess the relationship between gastrin levels and cirrhosis activity.

    Main Methods:

    • Serum gastrin levels were measured in the fasting state.
    • Fifty patients diagnosed with cirrhosis of the liver were included in the study.
    • Patients were categorized based on the cause (alcoholic vs. non-alcoholic) and activity (inactive vs. slightly active) of their cirrhosis.

    Main Results:

    • Fifty patients with cirrhosis exhibited elevated fasting serum gastrin concentrations.
    • Hypergastrinemia was more prevalent in patients with non-alcoholic cirrhosis compared to alcoholic cirrhosis.
    • Serum gastrin levels were significantly higher in patients with inactive cirrhosis than in those with slightly active cirrhosis.

    Conclusions:

    • Elevated serum gastrin is a common finding in patients with liver cirrhosis.
    • Non-alcoholic cirrhosis is associated with a higher incidence of hypergastrinemia.
    • Gastrin levels may correlate with the activity of liver cirrhosis, being higher in inactive stages.

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