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Meta-analysis and retrospective collaboration: two methods to map oligogenes for atopy and asthma
1University of Southampton, Wessex Human Genetics Institute, Southampton General Hospital, UK.
Abstract:
Combination of evidence over samples, each of which is too small to be conclusive, is the central problem in complex inheritance. There are three approaches: meta-analysis, prospective collaboration, and retrospective collaboration. Our experience with the first and last, which are the most cost-effective, is discussed.