Related Experiment Video
Updated: Aug 6, 2026
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
Follow-up study of peritoneal fluid kinetics in infants and children on peritoneal dialysis
A W de Boer1, T C van Schaijk, H L Willems
1Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Insights
Transcapillary ultrafiltration and marker clearance remain stable in children over 2.5 years on peritoneal dialysis. Fluid kinetics are similar in infants and older children using standard dialysis fluid volumes.
Area of Science:
- Pediatric Nephrology
- Peritoneal Dialysis
- Fluid Kinetics
Background:
- Understanding fluid and solute transport is crucial for optimizing peritoneal dialysis (PD) in children.
- Longitudinal data on lymphatic absorption and fluid kinetics in pediatric PD patients are limited, especially in infants.
Purpose of the Study:
- To assess longitudinal changes in transcapillary ultrafiltration (TCUF) and marker clearance (MC) in children undergoing PD.
- To evaluate fluid kinetics in infants (<2.5 years) using a standardized intraperitoneal volume.
Main Methods:
- A 4-hour dwell of dialysis fluid with Dextran 70 as a volume marker was used.
- Serial peritoneal equilibration tests (PETs) were conducted over 33 months in 20 children (aged 2.1-15.4 years).
- Fluid kinetics were measured in 5 infants (aged 0.5-2.5 years).
Main Results:
- TCUF and MC showed no significant longitudinal changes in children over 2.5 years.
- In infants, cumulative TCUF was 755 ± 237 mL/1.73 m² and cumulative MC was 400 ± 214 mL/1.73 m².
- Fluid kinetics did not differ between infants and older children with the specified intraperitoneal volume.
Conclusions:
- TCUF and MC are stable in children over 2.5 years on PD.
- Standardized intraperitoneal volumes ensure comparable fluid kinetics across different pediatric age groups.
Objectives:
To study longitudinal changes in transcapillary ultrafiltration (TCUF) and marker clearance (MC), as a reflection of lymphatic absorption, in children on peritoneal dialysis (PD). To present data on fluid kinetics in infants younger than 2.5 years, using an intraperitoneal volume of 1200 mL/m2 body surface area (BSA).
Design:
The study involved a 4-hour dwell of 1200 mL/m2 BSA of dialysis fluid containing 3.86% glucose with Dextran 70 as volume marker. Cumulative TCUF and cumulative MC were measured.
Setting:
A tertiary-care university hospital.
Patients:
A follow-up period of 33 months of serial (1 - 4) peritoneal equilibration tests (PETs) was studied in 20 children with a median age of 6.4 years (range 2.1 - 15.4 years). Fluid kinetics in 5 additional infants with a median age of 1.4 years (range 0.5 - 2.5 years) was measured.
Results:
Cumulative TCUF was 1041 mL/1.73 m2 at 1 - 3 months after start of PD, 1026 mL/1.73 m2 at 7 - 9 months, 1021 mL/1.73 m2 at 11 - 13 months, and 756 mL/1.73 m2 at 26 - 33 months (NS). Cumulative MC was 235 mL/1.73 m2 at 1 - 3 months after start of PD, 311 mL/1.73 m2 at 7 - 9 months, 395 mL/1.73 m2 at 11 - 13 months, and 509 mL/1.73 m2 at 26 - 33 months (NS). In infants, cumulative TCUF was 755 +/- 237 mL/1.73 m2; cumulative MC was 400 +/- 214 mL/1.73 m2.
Conclusions:
Transcapillary ultrafiltration and marker clearance do not change in children > 2.5 years during the period studied. Fluid kinetics does not differ between infants < 2.5 years and older children when intraperitoneal volumes of 1200 mL/m2 BSA are used.
Related Concept Videos
01:29Drug Dosing: Infants and Children
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
01:30Peritoneal Dialysis I: Introduction and Procedure
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
01:20Acute Kidney Injury V: Interprofessional Care