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Related Experiment Videos

HGF: a multifunctional growth factor controlling cell scattering.

M C Stella1, P M Comoglio

  • 1Institute for Cancer Research (I.R.C.C.), University of Torino Medical School, Candiolo, Torino, Italy. mcstella@hal.ircc.unito.it

The International Journal of Biochemistry & Cell Biology
|January 21, 2000
PubMed
Summary
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Hepatocyte Growth Factor (HGF), also known as Scatter Factor, is crucial for embryonic development and cell growth. This protein also plays a role in tumor cell invasion and is being investigated for therapeutic potential.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • Hepatocyte Growth Factor (HGF), or Scatter Factor, is a polypeptide homologous to blood coagulation enzymes.
  • It exists as an inactive precursor, activated by serine proteases into an alpha-beta heterodimer.
  • HGF exerts its effects by binding to its receptor, the MET proto-oncogene tyrosine kinase.

Purpose of the Study:

  • To elucidate the biological functions and signaling pathways of HGF/SF.
  • To investigate the role of HGF/SF in embryonic development and cellular processes.
  • To explore the involvement of HGF/SF in tumor cell invasion and its therapeutic potential.

Main Methods:

  • Analysis of HGF/SF structure and activation mechanism.
  • Investigation of HGF/SF signaling cascade via receptor binding and downstream effectors.

Related Experiment Videos

  • Utilizing knock-out mouse models to assess HGF/SF function in development.
  • In vitro and in vivo studies on HGF/SF's role in cell invasion and morphogenesis.

    • Main Results:

    • HGF/SF is essential for embryonic development, with knock-outs leading to lethality.
    • HGF/SF induces "branching morphogenesis," a complex process involving cell proliferation and motility.
    • HGF/SF promotes invasive behavior in various tumor cells.

    Conclusions:

    • HGF/SF is a critical signaling molecule with essential roles in development and cellular functions.
    • Its involvement in branching morphogenesis and tumor cell invasion highlights its complex biological activities.
    • HGF/SF presents potential as a therapeutic agent for conditions involving cell loss or proliferation disorders.