Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SPARC (osteonectin/BM-40).

K Motamed1

  • 1Department of Vascular Biology, The Hope Heart Institute, Seattle, WA 98122, USA. kmotamed@providence.org

The International Journal of Biochemistry & Cell Biology
|January 21, 2000
PubMed
Summary

Secreted Protein Acidic and Rich in Cysteine (SPARC) is a glycoprotein involved in embryogenesis, tissue repair, and regulating cell adhesion and proliferation. Its roles in cataract development and angiogenesis highlight its significance in biomedical research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of SPARC in the TRAMP model of prostate carcinogenesis and progression.

Oncogene·2009
Same author

IL6 suppression provides renal protection independent of blood pressure in a murine model of salt-sensitive hypertension.

Kidney & blood pressure research·2007
Same author

Peroxynitrite mediates VEGF's angiogenic signal and function via a nitration-independent mechanism in endothelial cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2007
Same author

SPARC-null mice exhibit increased adiposity without significant differences in overall body weight.

Proceedings of the National Academy of Sciences of the United States of America·2003
Same author

Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation.

Molecular biology of the cell·1999
Same author

SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells.

The Journal of biological chemistry·1998

Area of Science:

  • Biochemistry
  • Cell Biology
  • Developmental Biology

Background:

  • Secreted Protein Acidic and Rich in Cysteine (SPARC) is a key glycoprotein.
  • It interacts with cellular and extracellular matrix components.
  • SPARC plays roles in embryogenesis, tissue remodeling, and repair.

Purpose of the Study:

  • To summarize the known functions and significance of SPARC.
  • To highlight SPARC's involvement in processes like cataract development and angiogenesis.

Main Methods:

  • Literature review of SPARC's biological activities.
  • Analysis of SPARC's structural domains and their functions.
  • Examination of SPARC's role in various physiological and pathological processes.

Main Results:

  • SPARC is a modular 34 kDa protein with domains regulating cell adhesion, proliferation, and matrix metabolism.
  • Extracellular proteases rapidly degrade SPARC, leading to transient detection.
  • SPARC is implicated in cataract formation and angiogenesis in wound healing and tumors.

Conclusions:

  • SPARC is a crucial regulator of cellular and extracellular matrix interactions.
  • Its diverse roles in development and disease warrant further investigation.
  • Understanding SPARC's function is vital for biomedical applications.

Related Experiment Videos