Preretinal haemorrhages: an unusual manifestation of intravitreal amikacin toxicity
1Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institutes of Medical Sciences, New Delhi.
Purpose:
To report a case with multiple preretinal haemorrhages after intravitreal amikacin.
Method:
A 58-year-old patient developed postoperative endophthalmitis following a routine extracapsular cataract extraction in his left eye. He received two intravitreal injections of cephazoline (2.25 mg) and amikacin (0.4 mg), given 48 h apart.
Results:
The patient presented to us with large preretinal haemorrhages at the posterior pole. Multiple large areas of blocked fluorescence were seen on fundus fluorescein angiography.
Conclusion:
Widespread posterior pole preretinal haemorrhages may be an unusual manifestation of intravitreal amikacin toxicity.
Insights
Multiple preretinal hemorrhages occurred after intravitreal amikacin injection for endophthalmitis. This case highlights a potential, unusual toxicity of amikacin in the posterior pole.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Postoperative endophthalmitis is a serious complication following cataract surgery.
- Intravitreal antibiotics are a standard treatment for endophthalmitis.
Observation:
- A 58-year-old patient developed endophthalmitis after cataract surgery.
- The patient received two intravitreal injections of cephazoline and amikacin 48 hours apart.
Findings:
- The patient presented with extensive preretinal hemorrhages at the posterior pole.
- Fundus fluorescein angiography revealed multiple large areas of blocked fluorescence.
Implications:
- Widespread preretinal hemorrhages may represent an unusual manifestation of intravitreal amikacin toxicity.
- This finding warrants consideration of amikacin's potential side effects in managing endophthalmitis.
