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Postmortem investigation of lamotrigine concentrations
M G Pricone1, C V King, O H Drummer
1Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, Southbank, Australia.
Journal of Forensic Sciences
|January 21, 2000
Summary
This study establishes reference ranges for postmortem lamotrigine concentrations in various tissues. Elevated levels, especially when co-administered with valproic acid, highlight the need for careful monitoring in forensic toxicology.
Area of Science:
- Forensic Toxicology
- Clinical Chemistry
- Pharmacology
Background:
- Lamotrigine is an anticonvulsant with known therapeutic and toxic plasma concentration ranges.
- Limited data exists on postmortem lamotrigine concentrations and their interpretation.
- Potential for cardiac and neurological toxicity exists in lamotrigine overdose.