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Hyperbaric oxygen treatment and pulmonary function.

F Pott1, P Westergaard, J Mortensen

  • 1Center of Head and Orthopedics, Department of Clinical Physiology, Rigshospitalet, University of Copenhagen, Denmark.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|January 21, 2000
PubMed
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Hyperbaric oxygen therapy (HBO2) for mandibular osteoradionecrosis does not harm lung function. This treatment, even for patients with reduced diffusing capacity, shows no lasting negative effects on pulmonary parameters.

Area of Science:

  • Pulmonary Medicine
  • Hyperbaric Medicine
  • Oncology

Background:

  • Hyperbaric oxygen (HBO2) therapy can expose lungs to free radicals, potentially impairing pulmonary function.
  • HBO2 is effective for treating osteoradionecrosis of the mandible, a condition often following radiation for intraoral cancer.

Purpose of the Study:

  • To assess the impact of intermittent hyperbaric oxygen (HBO2) treatment on pulmonary function in patients with mandibular osteoradionecrosis.
  • To determine if HBO2 therapy causes persistent impairment of lung function, particularly in patients with pre-existing reduced diffusing capacity.

Main Methods:

  • 18 patients with mandibular osteoradionecrosis underwent 6 weeks of daily HBO2 treatment (90 min, 2.4 atm abs) in a monoplace chamber.
  • Pulmonary function tests, including forced vital capacity (FVC), 1-second forced expiratory volume (FEV1), total lung capacity (TLC), and carbon monoxide diffusing capacity (DLCO), were measured before and after treatment.

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Main Results:

  • Baseline pulmonary function tests showed values close to reference populations, with DLCO significantly lower (81% of expected).
  • After 6 weeks of HBO2 treatment, no significant changes were observed in FVC, FEV1, TLC, or DLCO relative to baseline values.
  • Individual parameter changes (delta) were minimal: deltaFVC +4%, deltaFEV1 -2%, deltaTLC +2%, deltaDLCO 0%, deltaRV 0%.

Conclusions:

  • Intermittent HBO2 treatment in a monoplace chamber does not result in persistent pulmonary function impairment.
  • HBO2 therapy can be safely administered to patients with osteoradionecrosis, even those with reduced lung diffusing capacity.