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Protein metabolism and the gut
F Mariotti1, J F Huneau, S Mahé
1INRA Unité Nutrition Humaine et Physiologie Intestinale, Institut National Agronomique Paris-Grignon, Paris, France.
Current Opinion in Clinical Nutrition and Metabolic Care
|January 21, 2000
Summary
The gut plays a crucial role in protein metabolism by controlling amino acid absorption and influencing nutrient availability to other organs, especially after eating. This highlights the gut
Area of Science:
- Gastroenterology and Metabolism
Background:
- The gut's role in protein metabolism is increasingly recognized.
- Emerging evidence highlights the gut's influence on amino acid flux and inter-organ metabolic relationships.
Purpose of the Study:
- To review the current literature on the gut's significance in extraintestinal protein metabolism.
- To elucidate the mechanisms by which the gut modulates amino acid availability.
Main Methods:
- Literature review of recent studies on gut protein metabolism.
- Analysis of the gut's function during the absorptive period.
Main Results:
- The gut actively controls amino acid absorption.
- The gut modulates the catabolism and synthesis of absorbed amino acids.
- Gut activity significantly impacts amino acid delivery to the liver and other organs.
Conclusions:
- The gut is a key regulator of amino acid metabolism and distribution.
- Understanding gut function is vital for comprehending whole-body protein metabolism.
- The gut's role is particularly critical during nutrient absorption.