Related Experiment Video
Updated: Aug 4, 2026
A Step by Step Protocol for Subretinal Surgery in Rabbits
Published on: September 13, 2016
[Intra-vitreal rt-PA and gas introduction in submacular hemorrhage]
M Buhl1, A Scheider, C L Schönfeld
1Universitäts-Augenklinik München.
Unlabelled:
Efficacy and complications of intravitreally injected tissue plasminogen activator (rt-PA) and sulfahexafluoride gas (SF6) in submacular hemorrhage are demonstrated.
Patients And Methods:
Fifty-three patients with submacular hemorrhage were treated (27 women, 26 men, mean age 79 +/- 1 years). Causes of hemorrhage were a choroidal neovascularization in 47 patients and macroaneurysm in 6 patients. After i.v. administration of 500 mg acetazolamide and disinfection of the conjunctiva, 50 micrograms rt-PA in 0.1 ml (BSS) and 0.5 ml SF6 were injected intravitreally. The patient was positioned prone for 24 h.
Results:
In 23 patients with choroidal neovascularization visual acuity improved by 2 lines and more; in 12 patients vision remained unchanged. In 12 patients visual acuity deteriorated. In 5 of 6 patients with a macroaneurysm vision improved from less than 0.1 to 0.1-0.5. Postoperative complications were four cases of vitreous hemorrhage and one case of endophthalmitis.
Conclusion:
The intravitreal injection of rt-PA and SF6 is an alternative method for treatment of submacular hemorrhage.
