Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leukoencephalopathy in multiple myeloma: two case reports.

C Lebrun1, S Chanalet, M Frenay

  • 1Service de Neurologie, Hôpital Pasteur, Nice, France.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|January 22, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-utility of oral methylprednisolone in the treatment of multiple sclerosis relapses: Results from the COPOUSEP trial.

Revue neurologique·2021
Same author

Atypical myelitis in patients with multiple sclerosis: Characterization and comparison with typical multiple sclerosis and neuromyelitis optica spectrum disorders.

Multiple sclerosis (Houndmills, Basingstoke, England)·2020
Same author

Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society.

Revue neurologique·2019
Same author

Digestive side-effects with teriflunomide: Thoughts on lactose.

Revue neurologique·2018
Same author

Inaugural tumor-like multiple sclerosis: clinical presentation and medium-term outcome in 87 patients.

Journal of neurology·2018
Same author

Demyelinating diseases.

Revue neurologique·2018

Leukoencephalopathy, a rare brain condition, is now linked to multiple myeloma. Chemotherapy improved symptoms and stabilized brain imaging in two patients, suggesting a direct link.

Area of Science:

  • Neurology
  • Oncology
  • Radiology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Leukoencephalopathy is a rare neurological disorder affecting white matter.
  • No prior reports linked leukoencephalopathy with multiple myeloma.

Observation:

  • Two patients presented with cognitive impairment.
  • Cognitive decline was associated with multiple myeloma.
  • Leukoencephalopathy was diagnosed in these patients.

Findings:

  • Chemotherapy demonstrated efficacy in treating neurological and biological markers.
  • Radiological evidence of leukoencephalopathy showed stabilization.
  • The findings suggest a direct association between the conditions.

Related Experiment Videos

Implications:

  • This association expands the understanding of multiple myeloma's potential neurological manifestations.
  • Leukoencephalopathy may represent a direct cerebral complication of malignant gammopathy.
  • Further research is warranted to elucidate the pathogenic mechanisms and treatment strategies.