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Related Experiment Videos

Nephromegaly in hyperalimentation.

S T Cochran, J J Pagani, Z L Barbaric

    Radiology
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Total parenteral nutrition (TPN) can cause nephromegaly, or enlarged kidneys, in some patients. However, this kidney enlargement did not affect renal function and reversed upon stopping TPN.

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    Area of Science:

    • Nephrology
    • Clinical Nutrition
    • Internal Medicine

    Background:

    • Hyperalimentation, particularly total parenteral nutrition (TPN), is a critical intervention for patients unable to meet nutritional needs orally.
    • The impact of prolonged nutritional support on organ size and function, specifically the kidneys, requires further investigation.
    • Understanding potential adverse effects of TPN is crucial for optimizing patient care and monitoring.

    Purpose of the Study:

    • To investigate the incidence of nephromegaly in patients receiving total parenteral nutrition (TPN).
    • To assess the effect of TPN-induced nephromegaly on renal function.
    • To determine if changes in renal size during TPN are reversible upon cessation of nutritional support.

    Main Methods:

    • Renal size was measured in 44 patients undergoing total parenteral nutrition (TPN).

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  • Kidney dimensions were assessed before, during, and after TPN in a subset of 26 patients.
  • Renal function was monitored throughout the study period.
  • Correlation between abnormal renal size and weight gain or liver function tests was analyzed.

    • Main Results:

    • Of 26 patients with pre-TPN measurements, 20 experienced an increase in kidney size, with 9 developing abnormally large kidneys.
    • No significant changes in renal function were detected during TPN, despite observed nephromegaly.
    • Kidney size returned to normal upon discontinuation of hyperalimentation.
    • Abnormal renal size did not correlate with weight gain or abnormal liver function tests.

    Conclusions:

    • Total parenteral nutrition (TPN) is associated with a notable incidence of nephromegaly.
    • TPN-induced nephromegaly does not appear to impair renal function.
    • The observed changes in renal size are reversible, indicating a temporary effect of nutritional support.