Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Updating working memory for words: a PET activation study.

C R Clark1, G F Egan, A C McFarlane

  • 1Cognitive Neuroscience Laboratory, School of Psychology, Flinders University of South Australia, Adelaide, Australia.

Human Brain Mapping
|January 22, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spigelian hernia: a multi-site review of operative outcomes of surgical repair in the adult population.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

Prevalence and implications of gambling problems among firefighters.

Addictive behaviors·2020
Same author

A population study of prolonged grief in refugees.

Epidemiology and psychiatric sciences·2019
Same author

Performance measures of 16- to 86-year-old males and females on the auditory verbal learning test.

The Clinical neuropsychologist·2017
Same author

Separation from parents during childhood trauma predicts adult attachment security and post-traumatic stress disorder.

Psychological medicine·2017
Same author

The longitudinal relationship between post-traumatic stress disorder and perceived social support in survivors of traumatic injury.

Psychological medicine·2016
Same journal

Brain Aging in Specific Phobia: An ENIGMA-Anxiety Mega-Analysis.

Human brain mapping·2026
Same journal

Talking to the Brain: Using Large Language Models as Proxies to Model Brain Semantic Features.

Human brain mapping·2026
Same journal

Emotional Context Modulates the Response to Somatosensory Stimuli Within 20 milliseconds.

Human brain mapping·2026
Same journal

GABAergic Modulation of Brain Function During Prosaccade and Antisaccade Eye Movements: Evidence From Ultra-High-Field fMRI.

Human brain mapping·2026
Same journal

Injury Severity Influences Long-Term Cognitive Control in Pediatric "Mild" Traumatic Brain Injury.

Human brain mapping·2026
Same journal

Early Adulthood Signatures of Motherhood in Brain Aging.

Human brain mapping·2026
See all related articles

This study used PET scans to identify brain regions involved in updating verbal working memory. Findings show the middle frontal gyrus (MFG) and supramarginal gyrus (SMG) are key for this cognitive process.

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Psychology

Background:

  • Verbal working memory is crucial for complex cognitive tasks.
  • Understanding the neural basis of controlled updating is essential for cognitive function research.

Purpose of the Study:

  • To investigate the cerebral regions involved in the controlled updating of verbal working memory using PET.
  • To elucidate the roles of the prefrontal and parietal cortices in this process.

Main Methods:

  • Positron Emission Tomography (PET) study with 10 healthy individuals.
  • Subjects performed a verbal updating task with two conditions: activating and control.
  • Monitored brain activity during word perception and target detection.

Main Results:

Related Experiment Videos

  • Bilateral activation was observed in the dorsolateral prefrontal cortex (middle frontal gyrus; MFG) and inferior parietal cortex (supramarginal gyrus; SMG).
  • MFG activation suggests executive control over working memory updating.
  • SMG activation indicates its role in binding modal representations of retained words.

Conclusions:

  • The MFG and SMG are critical for the controlled updating of verbal working memory.
  • Connections between MFG and SMG likely mediate stimulus-updating processes.
  • Combined activation relates to executive control in planned behavior and goal-setting.