Related Experiment Videos
5-HT5a receptors in the carotid body chemoreception pathway of rat
Z Y Wang1, I M Keith, M J Beckman
1Department of Comparative Biosciences, University of Wisconsin-Madison, 53706, USA. zwang@svm.vetmed.wisc.edu
Neuroscience Letters
|January 22, 2000
Abstract:
By using a specific antibody, 5-HT5a receptor-like immunoreactivity was revealed in the chemoreceptive, oxygen sensitive, carotid body (CB) type I cells, and neurons of the petrosal ganglion (PG) and the superior cervical ganglion (SCG) in rat. mRNA encoding for the 5-HTa receptor was also detected in these tissues by RT-PCR, and confirmed with DNA sequencing. The present study provides direct evidence that 5-HT5a receptors are expressed in the CB, PG and SCG, which all likely play fundamental roles in arterial chemoreception.