Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

5-HT system and cognition.

A Meneses1

  • 1Departamento de Farmacología y Toxicología, CINVESTAV-IPN, México D.F., Mexico. ameneses@df1.telmex.net.mx

Neuroscience and Biobehavioral Reviews
|January 22, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrahippocampal administration of 5-HT<sub>6</sub> receptor drugs on memory consolidation and amnesia protocols.

Behavioural brain research·2018
Same author

Effects of 5-HT<sub>5A</sub> receptor blockade on amnesia or forgetting.

Behavioural brain research·2018
Same author

5-HT7 receptor activation: procognitive and antiamnesic effects.

Psychopharmacology·2014
Same author

[High fidelity simulation in Spain: from dreams to reality].

Revista espanola de anestesiologia y reanimacion·2014
Same author

Effects of d-amphetamine on short- and long-term memory in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats.

Behavioural brain research·2010
Same author

[Brucella bacteremia reactivation 70 years after the primary infection].

Medecine et maladies infectieuses·2009

The serotonin (5-hydroxytryptamine or 5-HT) system significantly impacts learning and memory. Targeting various 5-HT receptors offers potential new treatments for cognitive disorders.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cognitive Science

Background:

  • The 5-hydroxytryptamine (5-HT) system, encompassing receptors 5-HT1 through 5-HT7, is increasingly recognized for its role in cognitive functions.
  • Evidence indicates that 5-HT pathways, transporters, and receptors are distributed in brain regions critical for learning and memory.

Purpose of the Study:

  • To explore the involvement of the 5-HT system in learning and memory processes.
  • To investigate the potential of modulating 5-HT receptors for treating cognitive disorders.

Main Methods:

  • Review of existing literature on 5-HT system components and their effects on cognition.
  • Analysis of how stimulation or blockade of specific 5-HT receptors (e.g., 5-HT1A, 5-HT2A/2C, 5-HT4) influences learning and memory.

Related Experiment Videos

Main Results:

  • Modulation of presynaptic and postsynaptic 5-HT receptors, as well as 5-HT uptake sites, affects learning and memory processes.
  • The 5-HT system plays a role in both normal cognitive function and the pathophysiology of cognitive impairments.

Conclusions:

  • The 5-HT system is a key player in learning, memory, and cognitive disorders.
  • Selective drugs targeting specific 5-HT receptors (agonists, antagonists, inverse agonists) represent a promising therapeutic avenue for cognitive alterations.